bs-80290C
[Life Science]
XIB4035
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:750.45
Formula:C26H31Cl2N3 · 3(H3PO4)
Purity:>98%
Solubility:Soluble in DMSO (up to 25 mg/ml with warming).
Chemical Name:(E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine, 3(H3PO4)
Formula:C26H31Cl2N3 · 3(H3PO4)
Purity:>98%
Solubility:Soluble in DMSO (up to 25 mg/ml with warming).
Chemical Name:(E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine, 3(H3PO4)
Description:
A novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor α-1 GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50=10.4 μM. Like GDNF, it induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells1. Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3 GDNF agonists may be a new class of Parkinson’s disease therapeutics.4
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.