bs-80285C
[Life Science]
HC-067047
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:471.51
Formula:C26H28F3N3O2
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Chemical Name:2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Formula:C26H28F3N3O2
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 10 mg/ml).
Chemical Name:2-Methyl-1-[3-(4-morpholinyl)propyl]-5-phenyl-N-[3-trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide
Description:
Potent reversible and selective TRPV4 antagonist. Active at mouse, human and rat TRPV4, IC50 = 17, 48 and 133 nM respectively. Also inhibits the endogenous TRPV4-mediated response to 4α-PDH (IC50 = 22 nM). Selective for TRPV4 over TRPV1, TRPV2, TRPV3 and TRPM8 channels1. Increases functional bladder capacity and reduces micturition frequency in mice and rats with cystitis1. Inhibits brain edema in middle cerebral artery occlusion mice2. Induces an increase in core body temperature accompanied by increased oxygen consumption in Wistar rats3. Active in vivo.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.