bs-80280C
[Life Science]
AI-1
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:265.70
Formula:C13H12ClNO3
Purity:>98%
Solubility:Soluble in DMSO (up to 15 mg/ml).
Chemical Name:4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
Formula:C13H12ClNO3
Purity:>98%
Solubility:Soluble in DMSO (up to 15 mg/ml).
Chemical Name:4-Chloro-1,2-dihydro-1-methyl-2-oxo-3-quinolinecarboxylic acid ethyl ester
Description:
A novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1 by AI-1 disrupts the ability of Keap1 to serve as an adaptor for Cul3-Keap1 ubiquitin ligase complex, thereby stabilizing and inducing transcriptional activation of Nrf2. A useful pharmacological tool for probing the involvement of Nrf2 in cellular physiology1. Cell permeable.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.