bs-80278C
[Life Science]
ML-297
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:328.32
Formula:C17H14F2N4O
Purity:>98%
Solubility:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 20 mg/ml).
Chemical Name:N-(3.4-Difluorophenyl)-n’-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
Formula:C17H14F2N4O
Purity:>98%
Solubility:Soluble in DMSO (up to 45 mg/ml) or in Ethanol (up to 20 mg/ml).
Chemical Name:N-(3.4-Difluorophenyl)-n’-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea
Description:
Selective GIRK ½ (Kir3.1/3.2) channel activator, IC50 = 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3 respectively. Has no effect on GIRK2, GIRK2/3, Kir2.1 and Kv7.4 channels.1,2 Displays antiseizure activity2 and decreases anxiety-related behavior without sedative or addictive effects3. Reduces glucose- and IBMX-stimulated GLP-1 secretion with no effect on GIP in murine L and K cells.4 Brain penetrant.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.