bs-80272C
[Life Science]
Salirasib (FTS)
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:358.54
Formula:C22H30O2S
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml) oe in Ethanol (up to 20 mg/ml)
Chemical Name:trans-Farnesylthiosalicylic acid
Formula:C22H30O2S
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml) oe in Ethanol (up to 20 mg/ml)
Chemical Name:trans-Farnesylthiosalicylic acid
Description:
Salirasib is a synthetic farnesylcysteine mimetic that inhibits ras proteins1,2 via disruption of interactions between the S-Prenyl moiety of Ras and the membrane anchorage domains3. It has been investigated in the treatment of various cancers.4,5 HCC cells pretreated with salirasib were sensitized to TRAIL-induced apoptosis.6 Salirasib has also been shown to inhibit TRPA1 (EC50 = 1.3 µM).7
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.