bs-80261C
[Life Science]
GSK-1702934A
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:396.5
Formula:C22H26N3O2S
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming)
Chemical Name:1-(1-(5,6,7,8-Tetrahydro=4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl)-1H-benzo[d]- imidazole-2(3H)-one
Formula:C22H26N3O2S
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml with warming)
Chemical Name:1-(1-(5,6,7,8-Tetrahydro=4H-cyclohepta[b]thiophene-2-carbonyl)piperidin-4-yl)-1H-benzo[d]- imidazole-2(3H)-one
Description:
TRPC3 activator. In whole-cell patch-clamp experiments in HEK293 cells transduced with recombinant human TRPC3 or TRPC6, GSK-1702934A activated the TRPC3 and TRPC6 current with EC50 of 0.08 µM and 0.44 µM respectively. In the rat cardiomyocyte-like cell line H9C2 GSK-1702934A (1 µM) activated TRPC6-like current and was completely blocked by GSK-417651A. It transiently increased the perfusion pressure of isolated rat heart retrogradely perfused via aortic cannulation at 1 µM1. Induces proarrhythmic and inotropic effects in TRPC3-overexpressing myocytes2.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.