bs-80259C
[Life Science]
680C91
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:238.27
Formula:C15H11FN2
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
Chemical Name:6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole
Formula:C15H11FN2
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 10 mg/ml)
Chemical Name:6-Fluoro-3-[(1E)-2-(3-pyridinyl)ethenyl]-1H-indole
Description:
A potent and selective inhibitor of tryptophan 2,3-dioxygenase (TDO) Ki=42 nM)1,2. Displays no activity against indoleamine 2,3-dioxygenase, MAO-A and B and does not effect serotonin uptake. Elevates CSF tryptophan by up to 260% and CSF serotonin by 170% of basal2. TDO inhibition by 680C91 in glioma cells blocked the release of kynurenine, an endogenous tumor promoting AHR ligand4.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.