bs-80256C
[Life Science]
ML-SA1
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:362.43
Formula:C22H22N2O3
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Chemical Name:2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Formula:C22H22N2O3
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml with warming) or in Ethanol (up to 10 mg/ml).
Chemical Name:2-[2-(3,4-Dihydro-2,2,4-trimethyl-1(2H)-quinolinyl)-2-oxoethyl]-1H-isoindole-1,3(2H)-dione
Description:
TRPML 1,2 and 3 channel activator.1 Does not activate TRPM2, TRPV2, TRPV3, TRPC6 or TRPA1 channels.2 ML-SA1 robustly activates whole cell TRPML1-4A and whole-endolysosome TRPML1 and is comparable (10 μM) to the effect of the endogenous TRPML agonist, PI(3,5)P2 (1 μM).2 Thus it is a useful chemical tool for studying the functions of TRPMLs. It induces TRPML-mediated Ca2+ release from lysosomes which corrects trafficking defects and reduces cholesterol accumulation in Niemann-Pick type C macrophages.2,3 Reduces intralysosomal Ca2+ level rescuing abnormal lysosomal storage in FIG4-deficient cells.4
Size: 10 mg, 50 mg10 mg, 50 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.