bs-80252C
[Life Science]
CCG-4986
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:374.8
Formula:C13H11ClN2O5S2
Purity:>98%
Solubility:Soluble in DMSO (up to 60 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
Chemical Name:Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate
Formula:C13H11ClN2O5S2
Purity:>98%
Solubility:Soluble in DMSO (up to 60 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
Chemical Name:Methyl-N-[(4-chlorophenyl)sulfonyl]-4-nitrobenzenesulfinimidoate
Description:
The first selective non-peptide inhibitor of the regulator of G protein signaling protein subtype RGS41. It covalently2-3 modifies RGS4 by inhibiting its interaction with Gα (IC50 = 3-5 µM) and suppressing GTPase activity1. Intratympanic administration of CCG-4986 was shown to rescue cochlear injury and hearing loss induced by acoustic overexposure and represents a novel paradigm for the treatment of sensorineural hearing loss via pharmacological regulation of GPCR signaling4. A novel tool for exploring the involvement of RGS4 in physiological processes5.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.