DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:366.42
Formula:C24H18N2O2
Purity:>98%
Solubility:Soluble in DMSO (up to 35 mg/ml).
Chemical Name:1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinolone-2,7-dione
Description:
Inhibits p90 ribosomal S6 kinase (RSK), IC50 = 1.2, 1.5 and 2.4 μM for RSK3, RSK1 and RSK2 respectively1. Induces a beta-cell-like state in pancreatic apha-cells and induces insulin expression1,2. Increases the endocrine cell content and function of donor human pancreatic islets in culture1. Blocks muscarinic acetylcholine receptor-stimulated RSK activation and subsequent proliferation of SNU-407 colon cancer cells3.