bs-80245C
[Life Science]
CZC-54252
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:541.46
Formula:C22H25ClN6O4S · HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml).
Chemical Name:N-[[[5-Chloro-2-[[2-methoxy-4-(4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-phenyl]methanesulfonamide hydrochloride
Formula:C22H25ClN6O4S · HCl
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml).
Chemical Name:N-[[[5-Chloro-2-[[2-methoxy-4-(4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]-phenyl]methanesulfonamide hydrochloride
Description:
Novel, potent and selective inhibitor of the leucine-rich repeat kinase-2 (LRRK2), IC50 = 1.28 nM. Also inhibits G2019S mutant LRRK2, IC50 = 1.85 nM1. Attenuates the neuronal damage elicited by the action of LRRK2 G2019S mutant in primary human neurons (EC50 = 1 nM)1. The G2019S mutant is a common mutation found in familial Parkinson’s disease patients2. Cell permeable.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.