bs-80243C
[Life Science]
ML-239
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:346.60
Formula:C13 H10 Cl3 N3 O2
Purity:>98%
Solubility:Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml), or in Ethanol (up to 25 mg/ml)
Chemical Name:(2,4,6-Trichlorophenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
Formula:C13 H10 Cl3 N3 O2
Purity:>98%
Solubility:Soluble in DMSO (up to 25 mg/ml), in DMF (up to 25 mg/ml), or in Ethanol (up to 25 mg/ml)
Chemical Name:(2,4,6-Trichlorophenoxy)-acetic acid (1H-pyrrol-2-ylmethylene)-hydrazide
Description:
A novel inhibitor of the growth and proliferation of breast cancer stem cells (CSC) discovered in a phenotypic screen employing CSC-like cells produced by inducing human breast epithelial cells into an epithelial-to-mesenchymal transdifferentiated state (HMLE_sh_ECad). ML239 displayed an IC50=1.18 μM against HMLE_sh_ECad and demonstrated a >23-fold selectivity over control cells. It was also toxic to two other CSC-like lines1,2. Gene expression studies showed altered gene expression in the NFκB pathway1 and support activation of fatty acid desaturase 2 (FADS2) as a potential mechanism of action for ML239.3
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.