bs-80239C
[Life Science]
KL-001
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:398.46
Formula:C21H22N2O4S
Purity:>98%
Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
Chemical Name:N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Formula:C21H22N2O4S
Purity:>98%
Solubility:Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
Chemical Name:N-[3-(9H-Carbazol-9-yl)-2-hydroxypropyl]-N-(2-furanylmethyl)methanesulfonamide
Description:
A novel tool that specifically interacts with cryptochrome (CRY) preventing its ubiquitin-dependent degradation resulting in lengthening of the circadian period. KL-001-mediated CRY stabilization inhibits glucagon-induced gluconeogenesis in primary hepatocytes1. Binds to the FAD-binding pocket of CRY2 as determined by co-crystal structure2. Induces an increase in period along with simultaneous reduction in amplitude of circadian reporter expression3 in mammalian cells.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.