bs-80229C
[Life Science]
GSK-J4
DATASHEET
Formulation wax
Storage: -20°C
Product Information:
Molecular Weight:417.48
Formula:C24H27N5O2
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Chemical Name:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Formula:C24H27N5O2
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Chemical Name:N-[2-(2-Pyridinyl)-6-(1,2,4,5-tetrahydro-3H-3-benzazepin-3-yl)-4-pyrimidinyl]-β-alanine ethyl ester
Description:
Histone demethylase JMJD3/UTX inhibitor. Inhibits demethylation of histone H3K27. Reduces LPS-induced proinflammatory cytokine production in primary human macrophages (IC50 = 9 μM for the inhibition of TNFα release). Cell permeable, ethyl ester of GSK J11. Rescues newborn pups from embryonic lethality in BRAF knockin mice which recapitulate major features of RASopathies2.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.