bs-80215C
[Life Science]
Spautin-1
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:271.27
Formula:C15H11F2N3
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Chemical Name:6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine
Formula:C15H11F2N3
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 15 mg/ml with warming).
Chemical Name:6-Fluoro-N[(4-fluorophenyl)methyl]-4-quinazolinamine
Description:
A specific and potent autophagy inhibitor. Spautin-1 promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin-specific proteases USP10 and USP13 which target the Beclin-1 subunit of Vps34 complexes1. Deranges dengue virion maturation2. Inhibits autophagy in a Beclin-1 independent manner in primary epithelial ovarian cancer cells3. Selectively induces cell death of mutant p53-expressing cancer cell lines under confluency4. Cell permeable.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.