DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:321.77
Formula:C15H16ClN3O3
Purity:>98%
Solubility:Soluble in DMSO (up to 15 mg/ml), or in Ethanol (up to 55 mg/ml).
Chemical Name:6-Chloro-7-[[2-(4-morpholinyl)ethyl]amino]-5,8-quinolinedione
Description:
Potent, selective and irreversible inhibitor of CDC25 phosphatases, Ki=29, 95 and 89 nM for human CDC25A, B2 and C respectively and >20- and >450-fold selective over VHR and PTP1B1. Arrests cells at G1 and G2/M and inhibits cdk1 and 2 activation2. Inhibits the growth of a variety of human tumor cell lines3. Acts via irreversible oxidation of the catalytic cysteine of CDC254.