DATASHEET
Formulation
powder
Storage:
RT
Product Information:
Molecular Weight:341.3 and 311.3
Formula:C17H11NO7 and C16H9NO6
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml)
Chemical Name:8-Methoxy-6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (A) and 6-nitro-phenanthro[3,4-d]-1,3-dioxole-5-carboxylic acid (B)
Description:
Phytochemical that acts as an anti-inflammatory and phospholipase A2 (PLA2) inhibitor (IC50 = 40 µM in human neutrophils)1. Its mutagenic properties cause tumorigenesis and kidney damage in rodent models and in humans2,3. Induces NF-κB, TGF-β, and oxidative stress in mouse kidney, and mitochondrial apoptosis in rat liver4,5.