bs-80187C
[Life Science]
A83-01
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:421.5
Formula:C25H19N5S
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml).
Chemical Name:3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Formula:C25H19N5S
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml).
Chemical Name:3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
Description:
Potent and selective ALK4, 5 and 7 inhibitor1,2. IC50=45, 12 and 7.5 nM respectively. Prevents phosphorylation of Smad2/3 and growth inhibition induced by TGFβ2. Inhibits differentiation of rat induced pluripotent stem cells and increases clonal expansion efficiency3. Together with AMI-5, A83-01 enabled Oct4-induced reprogramming of mouse embryonic fibroblasts4. Cell permeable. Active in vivo.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.