DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:397.65
Formula:C17H11Cl3N2O3
Purity:>98%
Solubility:Soluble in DMSO (up to 20 mg/ml).
Chemical Name:5-Chloro-1-[(2,5-dichlorophenyl)methyl]-1H-indole-2,3-dione 3-(O-acetyloxime)
Description:
Inhibits ubiquitin C-terminal hydrolase (UCH-L1) (Ki=0.4 M). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo. Cell permeable.