bs-80165C
[Life Science]
SR-1001
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:477.39
Formula:C15H13F6N6O4S2
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Chemical Name:N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide
Formula:C15H13F6N6O4S2
Purity:>98%
Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 40 mg/ml).
Chemical Name:N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide
Description:
A high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity1. It inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model3. Protects against pathologic neovascularization in various mouse models of retinopathy4. Active in vivo
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.