DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:167.19
Formula:C5H5N5S
Purity:>98%
Solubility:Soluble in DMF (up to 1.5 mg/ml with warming)
Chemical Name:2-Amino-6-mercaptopurine
Description:
After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo.1 It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1).2 Incorporates into DNA and induces double strand breaks which destabilize DNA structure resulting in cytotoxicity.3 Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in a xenograft model.4 Anticancer and immunosuppressive activity.