DATASHEET
Formulation
powder
Storage:
-20°C
Product Information:
Molecular Weight:224.2
Formula:C10H12N2O4
Purity:
Solubility:Soluble in DMSO (up to 20 mg/ml), or in Water (up to 20 mg/ml).
Chemical Name:2',3'-Didehydro-3'-deoxy-thymidine
Description:
Thymidine derivative that acts as an HIV nucleoside reverse transcriptase inhibitor (NRTI) (EC50 = 8.8 nM for HIV-1 replication in human PBMCs)1,2. Down-modulates P2X7-mediated NLRP3 inflammasome activation independent of reverse transcriptase inhibition3. Reduces production of IL-18 and caspase-1 and stimulates Aβ-induced autophagy in macrophages4.