bs-80137C
[Life Science]
Xestospongin C
DATASHEET
Formulation Lyophilized
Storage: -20°C
Product Information:
Molecular Weight:446.7
Formula:C28H50N2O2
Purity:>97%
Solubility:Soluble in DMSO (up to 10 mg/ml)
Chemical Name:Natural product isolated from the marine sponge Xestospongia sp.
Formula:C28H50N2O2
Purity:>97%
Solubility:Soluble in DMSO (up to 10 mg/ml)
Chemical Name:Natural product isolated from the marine sponge Xestospongia sp.
Description:
A potent and reversible inhibitor of IP3-mediated Ca2+ release, IC50 = 358 nM1. Experiments with guinea-pig ileum permeabilized with alpha toxin revealed that Xestospongin C inhibits the IP3 receptor but not the ryanodine receptor in SR membranes. In intact smooth muscle cells it inhibits voltage-dependent Ca2+ and K+ currents at a concentration range similar to that at which it inhibits the IP3 receptor. It is a useful tool for probing the involvement of IP3 receptors in cellular signaling3. Cell permeable.
Size: 10 ug, 50 ug10 ug, 50 ug
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.