bs-80121C
[Life Science]
XAV-939
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:312.31
Formula:C14H11F3N2OS
Purity:>98%
Solubility:Soluble in DMSO (up to 25 mg/ml).
Chemical Name:2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
Formula:C14H11F3N2OS
Purity:>98%
Solubility:Soluble in DMSO (up to 25 mg/ml).
Chemical Name:2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thiino[4,3-d]pyrimidin-4-ol
Description:
Tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively). Antagonizes Wnt signaling downstream of receptor activation via stabilization of axin, a negative regulator of β-catenin1. Robustly induces cardiomyogenesis of stem cells2. Reduces experimental fibrosis in a mouse model of bleomycin-induced dermal fibrosis3. Promotes apoptosis in a neuroblastoma cell line via telomere shortening4. An important tool for probing the activation of the Wnt/β-catenin pathway in cells5. Cell permeable.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.