bs-80113C
[Life Science]
A-769662
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:360.4
Formula:C20H12N2O3S
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
Chemical Name:4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
Formula:C20H12N2O3S
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 5 mg/ml),
Chemical Name:4-Hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile
Description:
A potent and reversible AMP-activated protein kinase (AMPK) allosteric activator. Activates AMPK by binding to the β and γ subunits and not the AMP binding site1. EC50=0.8 µM for purified rat liver AMPK and inhibits fatty acid biosynthesis in rat hepatocytes IC50=3.2 µM2. Inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces plasma and liver triglycerides and lowers plasma glucose in ob/ob mice2. Inhibits adipocyte differentiation3. Prevents transcriptional activation of Oct4 and establishes a metabolic barrier to induced pluripotent stem cell reprogramming4. Synergizes with AICAR5. Cell permeable.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.