bs-80056C
[Life Science]
Tesmilifene HCl
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:283.42
Formula:C19H25NO
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Water (up to 75 mg/ml).
Chemical Name:N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine hydrochloride
Formula:C19H25NO
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml) or in Water (up to 75 mg/ml).
Chemical Name:N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine hydrochloride
Description:
Tesmilifene, an analog of tamoxifen, acts as a chemopotentiator and antineoplastic agent and was developed for the treatment of breast cancer but never marketed1. It binds with high affinity to the anti-estrogen binding site (AEBS) in rat liver microsomes but does not bind to the estrogen receptor (at or below 10 µM) 2. Displaces histamine from AEBS, an activity which correlates with its cytotoxic effects on breast cancer cells2. Enhances the cytotoxicity of taxol, epirubicin, doxorubicin and vinorelbine in multidrug resistance cell lines3. It has been shown to increase the permeability of the blood-brain and blood-glioma barrier in culture and animal models by modifying brain endothelial functions4.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.