bs-80025C
[Life Science]
ZM-447439
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:513.59
Formula:C29H31N5O4
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Chemical Name:N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Formula:C29H31N5O4
Purity:>98%
Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Chemical Name:N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide
Description:
ZM-447439 is a selective ATP-competitive inhibitor of Aurora kinase B1 (IC50 = 50 nM, Aur A IC50 = 1 µM, Aur C IC50 = 250 nM at physiological ATP concentrations2, Ref.1 lists Aur A IC50 = 110nM and Aur B IC50 = 113nM). It did not significantly inhibit a panel of 14 other kinases including mitotic kinases CDK1 and PLK1. It prevents chromosome alignment, spindle checkpoint function and cytokinesis.1,2
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.