bs-80017C
[Life Science]
Dorsomorphin
DATASHEET
Formulation powder
Storage: -20°C
Product Information:
Molecular Weight:399.49
Formula:C24H25N5O
Purity:>98%
Solubility:Soluble in DMSO (up to 3 mg/ml).
Chemical Name:6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
Formula:C24H25N5O
Purity:>98%
Solubility:Soluble in DMSO (up to 3 mg/ml).
Chemical Name:6-[4-[2-(1-Piperidinyl)ethoxy]phenyl]-3-(4-pyridinyl)-pyrazolo[1,5-a]pyrimidine
Description:
Potent, selective and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM).1 It displays no significant inhibition of ZAPK, SYK, PKCT, PKA and JAK3. It inhibits bone morphogenetic protein (BMP) type I receptors (ALK2, ALK3 and ALK6).2 Dorsomorphin has been shown to promote cardiomyogenesis in mouse embryonic stem cells (ESCs) in vitro.3 Induces autophagy in cancer cell lines via a mechanism independent of AMPK inhibition.4
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.