bs-80006C
[Life Science]
Arecoline HBr
DATASHEET
Formulation powder
Storage: RT
Product Information:
Molecular Weight:236.11
Formula:C8H13NO2 HBr
Purity:>98%
Solubility:Soluble in Water (up to 50 mg/ml).
Chemical Name:1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide
Formula:C8H13NO2 HBr
Purity:>98%
Solubility:Soluble in Water (up to 50 mg/ml).
Chemical Name:1,2,5,6-Tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide
Description:
Tyrosine407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is “hijacked” and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50=11.1 μM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass.1 Agonist at muscarinic acetylcholine receptors M1 – M5 (EC50 in the range of 7-410 nM).2 May be effective in dementia.3
Size: 250 mg, 1 g250 mg, 1 g
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.