bs-80001C
[Life Science]
GSK-3787
DATASHEET
Formulation Powder
Storage: -20°C
Product Information:
Molecular Weight:392.8
Formula:C15H12ClF3N2O3S
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml).
Chemical Name:4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
Formula:C15H12ClF3N2O3S
Purity:>98%
Solubility:Soluble in DMSO (up to 30 mg/ml).
Chemical Name:4-Chloro-N-(2-{[5-(trifluoromethyl)-2-pyridyl]sulfonyl}ethyl)benzamide
Description:
Selective and irreversible antagonist of peroxisome proliferator-activated receptor beta/delta (PPARβ/δ) (plC50 = 6.6), but not PPARα or ɣ1,2. It covalently binds to Cys 249 in the PPARβ/δ binding site1. When applied topically, GSK-3787 showed efficacy against an inflammatory skin disease resembling psoriasis in mice3. Suppresses colorectal cancer tumorigenesis in Apc(δ580) mice4.
Size: 5 mg, 25 mg5 mg, 25 mg
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.