bs-75888C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 84687-43-4

Molecular formula: C41H68O14

Molecular weight: 784.98

Purity: >98% (HPLC)

Appearance: White to off-white powder.

Solubility: Soluble in DMSO (30mg/ml) or DMF (20mg/ml).

InChiKey: QMNWISYXSJWHRY-RXMVGYINSA-N

SMILES: O[C@H]1C[C@@]2(C)[C@]3([H])C[C@H](O[C@@H]4O[C@H](CO)[C@@H](O)[C@H](O)[C@H]4O)[C@@]5([H])C(C)(C)[C@@H](O[C@H]6OC[C@@H](O)[C@H](O)[C@H]6O)CC[C@]57[C@]3(C7)CC[C@]2(C)[C@H]1[C@]8(C)O[C@H](C(C)(O)C)CC8

Description:

Astragaloside IV (AS-IV) is a bioactive saponin and constituent of the traditional chinese medicine plant Astragali radix. AS-IV has multiple pharmacologic effects, including anti-inflammatory, antioxidative, anti-asthma, antidiabetes, anticancer, immunoregulation, neuroprotective and cardioprotective properties via numerous signaling pathways. This includes inhibition of NF-kappaB, inducing hypoxia-inducible factor-1alpha accumulation via PI3K/Akt pathway, reducing Abeta production in Alzheimer's disease through inhibition of BACE1, working as a natural PPARgamma agonist, improving lipid metabolism in obese mice, enhancing chemosensitivity through CD276 (B7-H3)-pathway inhibition, and suppressing glucose-induced NLRP3 inflammasome activation.