bs-75878C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 520-36-5

Molecular formula: C15H10O5

Molecular weight: 270.24

Purity: >95% (HPLC)

Appearance: Yellow to brown powder.

Solubility: Soluble in DMSO (10mg/ml) or DMF (20mg/ml).

InChiKey: KZNIFHPLKGYRTM-UHFFFAOYSA-N

SMILES: OC1=C2C(OC(C3=CC=C(O)C=C3)=CC2=O)=CC(O)=C1

Description:

Apigenin is an antioxidant plant flavonoid with anti-inflammatory, angiogenic, neuroprotective and anticancer properties. It may induce apoptosis and inhibit proliferation of tumor cells by arresting the cell cycle at the G2/M phase. Inhibits tumor angiogenesis through decreasing HIF-1alpha and VEGF expression. Also known to be a MAP kinase inhibitor and a selectively inhibitor of casein kinase 2 (CK2). It is a potent inhibitor of the synthesis of the inflammatory mediators nitric oxide and prostaglandin E2, reducing inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Shown to selectively inhibits chymotrypsin-like and trypsin-like proteasome catalytic activity.