bs-75815C

DATASHEET

Formulation Powder

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 95633-27-5

Molecular formula: C10H7N3O2

Molecular weight: 201.18

Purity: >98% (HPLC)

Appearance: Yellow powder.

Solubility: Soluble in DMSO.

InChiKey: HEKDKVLIMUWRRZ-UHFFFAOYSA-N

SMILES: CC1=CC(=O)OC2=CC(=CC=C12)N=[N+]=[N-]

Description:

7-Azido-4-methylcoumarin is a highly sensitive and selective fluorogenic H2S probe. The aromatic azide moiety of AzMC is selectively reduced in the presence of H2S, producing the fluorescent 7-amino-4-methylcoumarin (AMC) with a concomitant increase in fluorescence with lambdaex = 365 nm and lambdaem = 450 nm. It is a photoaffinity labeling probe for the substrate binding site of human sulfotransferase 1A1 (SULT1A1). 7-Azido-4-methylcoumarin is a tool for monitoring the activity of pyridoxal-5'-phosphate (PLP)-dependent enzymes (e.g. cystathionine beta-synthase (CBS), cystathionine gamma-lyase (CGL) and tryptophan synthase (TS)) and to identify novel cystathionine beta-synthase (CBS) inhibitors and activators.