DATASHEET
Formulation
Solid
Storage:
Stable for 1 year after receipt when stored at +4°C. After reconstitution protect from light at -20°C.
Product Information:
CAS Number: 641-38-3
Molecular formula: C14H10O5
Molecular weight: 258.2
Purity: >98% (HPLC)
Appearance: Light brown solid.
Solubility: Soluble in DMSO (20mg/ml) or DMF. Slightly soluble in acetone (1mg/ml).
InChiKey: CEBXXEKPIIDJHL-UHFFFAOYSA-N
SMILES: OC1=CC(C2=C(C)C=C(O)C=C2O3)=C(C(O)=C1)C3=O
Description:
Mycotoxin. Phytotoxin. Shows cytotoxic, teratogenic, mutagenic and genotoxic properties by DNA intercalation. Induces several types of DNA damage, including oxidative DNA damage, single-stranded DNA breaks (SSB) and double-strand, through AOH-induced ROS production and interaction with DNA topoisomerase. Inhibits the activity of topoisomerase IIalpha in mammalian cells. Induces cell growth arrest in G2/M phase. GSK-3beta inhibitor (sub-µM IC50 values). Antiviral activity (herpes simplex). Hepatitis C NS3-4A protease inhibitor. Induces cytochrome P450 1A1 expression and apoptosis in mouse hepatoma cells.