bs-75685C

DATASHEET

Formulation Powder

Storage: Stable for 1 year after receipt when stored at -20°C. After reconstitution protect from light at -20°C.

Product Information:

CAS Number: 7184-60-3

Molecular formula: C28H43NO6

Molecular weight: 489.6

Purity: >98% (HPLC)

Appearance: White to off-white powder.

Solubility: Soluble in DMSO or methanol.

InChiKey: OJCKRNPLOZHAOU-TVHKGLGPSA-N

SMILES: [H][C@]1(CCC[C@H]1C(O)=O)[C@]1([H])C\C=C\C=C(C#N)/[C@H](O)[C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@@H](O)CC(=O)O1

Description:

Macrolide antibiotic. Bacterial, protozoan and mammalian threonyl-tRNA synthetase (THrRS) inhibitor. Antiangiogenic (IC50 = 0.8 nM) and anticancer agent. Induces the collapse of formed capillary tubes in a dose-dependent fashion. In HUVECs, the capillary tube collapsing activity is mediated by the activation of caspases-3 and -8 and induction of apoptosis. Blocks the formation of spontaneous lung metastases of B16-BL6 melanoma cells. Cyclin-dependent kinase (CDK) inhibitor. Antiviral. Potent antimalarial agent (IC50 = 0.97 nM). Inhibitor of potato scab disease.