bs-75647C
[Life Science]
Leucettine L41
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 1112978-84-3
Molecular formula: C17H13N3O3
Molecular weight: 307.3
Purity: >98% (NMR)
Appearance: Beige solid.
Solubility: Soluble in DMSO or ethanol.
InChiKey: PGPHHJBZEGSUNE-JYRVWZFOSA-N
SMILES: O=C1NC(NC2=CC=CC=C2)=N\C1=C/C1=CC2=C(OCO2)C=C1
Molecular formula: C17H13N3O3
Molecular weight: 307.3
Purity: >98% (NMR)
Appearance: Beige solid.
Solubility: Soluble in DMSO or ethanol.
InChiKey: PGPHHJBZEGSUNE-JYRVWZFOSA-N
SMILES: O=C1NC(NC2=CC=CC=C2)=N\C1=C/C1=CC2=C(OCO2)C=C1
Description:
Potent inhibitor of DYRKs (DYRK1A (IC50=40nM); DYRK2 (IC50=35nM)) and CLKs (CLK1, CLK3). Interacts also with GSK-3alpha/beta, CK2 and PIM1. Interacts with the complex PIKfyve/Vac14/Fig4. Modulates alternative splicing of pre-mRNA in various cellular systems. Neuroprotective against APP-induced cell death. Tools to study and modulate pre-RNA splicing. Potential compound for Alzheimer's disease and diseases involving abnormal pre-mRNA splicing. Potential compound to study Down syndrome (inhibition of DYRK1A). Neuroprotective against glutamate-induced cell death. Autophagy activator.
Size: 1mg,5mg,25mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.