DATASHEET
Formulation
Solid
Storage:
Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 394730-60-0
Molecular formula: C27H45N5O5
Molecular weight: 519.7
Purity: >95% (NMR)
Appearance: White to off-white solid.
Solubility: Soluble in DMSO (15mg/ml), ethanol (20mg/ml) or DMF (20mg/ml).
InChiKey: LHHCSNFAOIFYRV-DOVBMPENSA-N
SMILES: [H][C@]1(C2(C)C)[C@]2([H])CN(C([C@H](C(C)(C)C)NC(NC(C)(C)C)=O)=O)[C@]1([H])C(NC(CC3CCC3)C(C(N)=O)=O)=O
Description:
The antiviral agent boceprevir is a protease inhibitor that covalently and reversibly binds to the catalytic site (Ser139) of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A), a serine protease that is essential for viral replication (Ki = 14nM) by cleaving the virally encoded polyprotein into mature proteins like NS4A, NS4B, NS5A and NS5B. It inhibits the NS3/4A protease in an in vitro HCV replicon system with an EC50 value of 200 nM. Boceprevir has been identified as a potential inhibitor of SARS-CoV-2 responsible for COVID-19. It inhibits SARS-CoV-2 viral replication by targeting the viral main protease Mpro (IC50 = 4.13µM).