bs-75609C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 147098-20-2

Molecular formula: C22H27FN3O6S . 1/2Ca

Molecular weight: 480.6 . 20.0

Purity: >98% (HPLC)

Appearance: White to off-white solid.

Solubility: Soluble in DMSO (20mg/ml) or DMF (20mg/ml).

InChiKey: VGAZDTHGPVFCCO-YFRSHGDPSA-K

SMILES: CN(S(C)(=O)=O)C1=NC(C2=CC=C(F)C=C2)=C(/C=C/[C@H](C[C@@H](O)CC([O-])=O)O)C(C(C)C)=N1.[Ca+2]

Description:

Rosuvastatin is a potent competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the statin class of cholesterol-lowering drugs. Rosuvastatin is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease. Formulations containing rosuvastatin reduce low-density lipoprotein (LDL) and C-reactive protein and increase high-density lipoprotein (HDL) in humans. Shown to have anti-inflammatory, antioxidant, antithrombotic and insulin sensitizing properties. Identified as a potential inhibitor of SARS-CoV-2, responsible for COVID-19.