bs-75590C
[Life Science]
Sunitinib . malate
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 341031-54-7
Molecular formula: C22H27FN4O2 . C4H6O5
Molecular weight: 398.5 . 134.1
Purity: >98%
Appearance: Solid.
Solubility: Soluble in DMSO (10mg/ml) or ethanol.
InChiKey: LBWFXVZLPYTWQI-IPOVEDGCSA-N
SMILES: O[C@@H](CC(O)=O)C([O-])=O.[H][N+](CC)(CC)CCNC(=O)C1=C(C)NC(\C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C
Molecular formula: C22H27FN4O2 . C4H6O5
Molecular weight: 398.5 . 134.1
Purity: >98%
Appearance: Solid.
Solubility: Soluble in DMSO (10mg/ml) or ethanol.
InChiKey: LBWFXVZLPYTWQI-IPOVEDGCSA-N
SMILES: O[C@@H](CC(O)=O)C([O-])=O.[H][N+](CC)(CC)CCNC(=O)C1=C(C)NC(\C=C2/C(=O)NC3=C2C=C(F)C=C3)=C1C
Description:
Potent ATP-competitive and cell permeable multi-targeted receptor tyrosine kinase (RTK) inhibitor targeting VEGFR and PDGFR-beta. Inhibits FLK1 (Ki=9nM), PDGFRbeta (Ki=8nM) and FLT3. It is at least 10-fold selective for FLK1 and PDGFRbeta over a variety of tyrosine kinases in a panel, including EGFR, Cdk2, Met, IGFR-1, Abl and Src. Inhibits the cellular receptor phosphorylation of FLT3, RET and CSF-1R. Also shown to inhibit c-Kit. Exhibits potent antiangiogenic and antitumor activity in multiple xenograft models.
Size: 1mg,5mg,25mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.