bs-75559C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 1072833-77-2

Molecular formula: C14H19BCl2N2O4

Molecular weight: 361

Purity: >98% (HPLC)

Appearance: White solid.

Solubility: Soluble in DMSO (20mg/ml), ethanol (10mg/ml) or DMF (20mg/ml). Poorly soluble in aqueous buffers.

InChiKey: MXAYKZJJDUDWDS-LBPRGKRZSA-N

SMILES: OB([C@H](CC(C)C)NC(CNC(C1=C(Cl)C=CC(Cl)=C1)=O)=O)O

Description:

Potent selective and reversible proteasome inhibitor (all proteolytic subunits). Targets the chymotrypsin-like beta5 subunit of the constitutive 20S proteasome (IC50=3.4nM). Cross-reacts and inhibits the trypsin-like beta2 subunit (IC50=3.5µM) and the caspase-like/peptidyl-glutamyl peptide-hydrolyzing (PGPH) beta1 subunit (IC50=0.03µM). Anticancer compound effective in cell-based assays, in xenografts and against multiple myeloma in vivo. In vitro, induces cell cycle arrest and apoptosis in human cancer cell lines including multiple myeloma. Biologically active form of the prodrug MLN9708 (Prod. No. bs-75560C). Exhibits improved pharmacodynamics and antitumor activity compared to bortezomib (Prod. No. bs-75509C) in various B cell lymphoma models, due to a greater tumor to blood ratio of proteasome inhibition that ultimately translates into improved tumor pharmacodynamic response and antitumor activity in several tumor xenograft models.