bs-75553C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 1047953-91-2

Molecular formula: C19H17Cl3N4O3

Molecular weight: 455.7

Purity: >98%

Appearance: White to off-white solid.

Solubility: Soluble in DMSO (30mg/ml) or ethanol (5mg/ml).

InChiKey: TWJGQZBSEMDPQP-UHFFFAOYSA-N

SMILES: COCCOC1=NN(C2=CC=C(NC(CCl)=O)C=C2)C(C3=CC=C(Cl)C(Cl)=C3)=N1

Description:

Highly potent and selective irreversible MALT1 inhibitor (IC50=5.8µM). Binds directly to MALT1 and suppresses protease function. Decreases NF-kappaB activity induced by MALT1. Inhibits cell proliferation and MALT1-mediated cleavage activity. Suppresses human TMD8 and HBL-1 (EC50= ~200nM and ~500nM for HBL-1 and TMD8, respectively) activated B cell-like diffuse large B cell lymphoma (ABC-DLBCL) cell lines in vitro and xenotransplanted mouse ABC-DLBCL tumors in vivo and primary human ABC-DLBCLs ex vivo. In combination with bryostatin 1 displays selective killing of HIV latently infected CD4+ T cells. Inhibits NF-kappaB and NLRP3 inflammasome activation in macrophages. Decreased production of IL-1beta/IL-18 in PMA-differentiated THP-1 cells and bone marrow derived macrophage via suppressing the activation of NF-kappaB and NLRP3 inflammasome.