bs-75550C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 264218-23-7

Molecular formula: C16H10ClN3O5

Molecular weight: 359.7

Purity: >97%

Appearance: Yellow solid.

Solubility: Soluble in DMSO (10mg/ml), ethanol (5mg/ml) or methanol.

InChiKey: PQCXVIPXISBFPN-UHFFFAOYSA-N

SMILES: ClC1=CC(NC2=C(C3=C([N+]([O-])=O)C=CC=C3)C(NC2=O)=O)=CC=C1O

Description:

Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM (and similar potency for GSK3beta). DYRK1A inhibitor (IC50=0.9µM). Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription. Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. Anticancer agent with antiproliferative activity. Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation.