bs-75549C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 1594092-37-1

Molecular formula: C24H27N7O

Molecular weight: 429.5

Purity: >98%

Appearance: White to off-white solid.

Solubility: Soluble in DMSO (5mg/ml), ethanol (2mg/ml) or DMF (2mg/ml).

InChiKey: ZYVXTMKTGDARKR-UHFFFAOYSA-N

SMILES: CN1C2=C(C=CN=C2)C(C3=CC=NC(NC4=C(OC)C=C(N5CCN(C)CC5)C=C4)=N3)=C1

Description:

Cell permeable azaindole that inhibits the serine/threonine kinase activity of DYRK1B (IC50=17nM) with 5-fold and 110-fold selectivity against the related family members DYRK1A and DYRK2, respectively. Used as a probe to elucidate the mechanism of DYRK1B regulation of cell cycle progression. Dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B (DYRK1B) belongs to a family of nuclear-localized protein kinases and participates in the regulation of the cell cycle with key roles in proliferation and differentiation. It is upregulated in solid tumors and gain-of-function mutations in the gene encoding this kinase have been linked to metabolic syndrome.