bs-75545C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

Product Information:

CAS Number: 1680206-61-4

Molecular formula: C20H32O4

Molecular weight: 336.5

Purity: >98% (HPLC)

Appearance: Orange solid.

Solubility: Soluble in DMSO (1mg/ml), ethanol or chloroform. Insoluble in water.

InChiKey: ROJYDZSFBXLWIR-UHFFFAOYSA-N

SMILES: CCCCCCCCCCCCC(C1=O)=C(OC)C(OC)=CC1=O

Description:

Selective and reversible potent inhibitor of human 5-lipoxygenase (5-LO). This enzyme catalyzes two initial steps in the conversion of arachidonic acid into leukotrienes, well known mediators of inflammatory and allergic reactions. Potently inhibits 5-LO product synthesis intact human leukocytes, such as neutrophils and monocytes (IC50>22nM) and in cell-free assays (IC50>140nM) without affecting 12/15-LOs, cyclooxygenase (COX)-1/2 or arachidonic acid release. Anti-inflammatory compound. Shows pronounced effectiveness in different models of inflammation in vivo at 0.1 mg/kg; i.p. Impaired (I) bronchoconstriction in ovalbumin-sensitized mice challenged with acetylcholine, (II) exudate formation in carrageenan-induced paw edema and (III) zymosan-induced leukocyte infiltration in air pouches.