bs-75531C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 915019-65-7

Molecular formula: C30H23N5O

Molecular weight: 469.5

Purity: >98%

Appearance: White to off-white solid.

Solubility: Soluble in dimethylformamide (~10mg/ml). Sligthly soluble in DMSO or chloroform (~1mg/ml). Warming and sonication might be necessary. Insoluble in water.

InChiKey: JOGKUKXHTYWRGZ-UHFFFAOYSA-N

SMILES: CN(C1=CN=C(C=CC(C2=CC(C=CC=C3)=C3N=C2)=C4)C4=C1N5C6=CC=C(C(C)(C)C#N)C=C6)C5=O

Description:

Potent dual ATP-competitive pan class I PI3K and mTOR inhibitor (p110alpha/gamma/delta/beta and mTOR(p70S6K) with IC50 of 4nM, 5nM, 7nM, 75nM and 6nM, respectively), subsequently inducing G1 phase arrest in biological cell growth and viability assays. Anticancer compound. Antiproliferative against several animal tumor cell lines, specifically blocking the dysfunctional activation of the PI3K pathway, Enhances the efficacy of other anticancer agents when used in in vivo combination studies. Strongly inhibits VEGF-induced cell proliferation and survival in vitro and VEGF-induced angiogenesis in vivo. Shown to be a potent inhibitor of ATM- and DNA-PKCs-mediated DNA damage and DNA double-strand break repair. Shown to have neuroprotective properties on amyloid-beta 1-42 induced neurotoxicity and memory impairment. Shows anti-trypanosomal activity for some selected species.