bs-75525C
[Life Science]
CK2 Inhibitor 10
DATASHEET
Formulation Solid
Storage: Stable for 2 years after receipt when stored at -20°C.
Product Information:
CAS Number: 1361229-76-6
Molecular formula: C18H14N2O4S . 0.5H2O
Molecular weight: 354.4 . 9.0
Purity: >98% (HPLC, MS, NMR)
Appearance: Off-white to pale yellow solid.
Solubility: Soluble in DMSO. Insoluble in water.
InChiKey: UPIVZLFKYMNZDG-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C(=O)NC1=NC=C(S1)C1=CC=C(C=C1)C(O)=O
Molecular formula: C18H14N2O4S . 0.5H2O
Molecular weight: 354.4 . 9.0
Purity: >98% (HPLC, MS, NMR)
Appearance: Off-white to pale yellow solid.
Solubility: Soluble in DMSO. Insoluble in water.
InChiKey: UPIVZLFKYMNZDG-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C(=O)NC1=NC=C(S1)C1=CC=C(C=C1)C(O)=O
Description:
Potent and ATP-competitive inhibitor of casein kinase 2 (IC50 CK2alpha=32nM and IC50 CK2alpha'=46nM). Potently also inhibits DYRK1B and FLT3. Anticancer compound. Exhibits potent cytotoxicity towards lung cancer cells A549, colorectal cancer cells HCT-116 and breast cancer cells MCF-7. Promoted cAMP-induced thermogenesis in white adipocytes. CK2 inhibition ameliorates diet-induced obesity and insulin resistance in mice in vivo by promoting UCP1-dependent thermogenesis.
Size: 1mg,5mg,
Applications: Life Science()
For research use only. Not intended for diagnostic or therapeutic use.