DATASHEET
Formulation
Solid
Storage:
Stable for 3 years after receipt when stored at -20°C.
Product Information:
CAS Number: 864070-44-0
Molecular formula: C23H27ClO7
Molecular weight: 450.9
Purity: >98% (HPLC)
Appearance: White solid.
Solubility: Soluble in DMSO. Slightly soluble in water or ethanol.
InChiKey: OBWASQILIWPZMG-QZMOQZSNSA-N
SMILES: OCC1O[C@H](C(O)[C@@H](O)[C@@H]1O)C1=CC(CC2=CC=C(O[C@H]3CCOC3)C=C2)=C(Cl)C=C1
Description:
Antidiabetic agent. Potent and selective sodium glucose co-transporter 2 (SGLT-2) inhibitor. >300-fold selectivity over SGLT-1, 4, 5 and 6. SGLT-2 is found almost exclusively in the proximal tubules of nephronic components in kidneys. Inhibition of SGLT-2 reduces blood glucose by blocking renal glucose reabsorption and thereby increasing urinary glucose excretion (UGE). Shown to preserves beta cell mass and restore glucose homeostasis.