bs-75510C

DATASHEET

Formulation Solid

Storage: Stable for 1 year after receipt when stored at -20°C.

Product Information:

CAS Number: 300815-04-7

Molecular formula: C13H14Cl3N7O4

Molecular weight: 438.7

Purity: >98% (HPLC)

Appearance: White to off-white solid.

Solubility: Soluble in DMSO (20mM).

InChiKey: ZEXHXVOGJFGTRX-UHFFFAOYSA-N

SMILES: CC1=NC=C(N1CCOC(=O)NC(NC1=NC=CC=N1)C(Cl)(Cl)Cl)[N+]([O-])=O

Description:

Cell permeable compound capable of slowing anaphase-promoting complex/cyclosome (APC/C)-dependent proteolysis. Inhibitor of the ubiquitin ligase activity of the APC/C by inhibiting substrate binding to Cdc20. Distinct mechanism of action than proTAME. Blocks mitotic exit only modestly when used alone in cultured cells. A strong synergistic effect is observed when Apcin and proTAME are used simultaneously, providing a more robust mitotic arrest. This may be very beneficial when treating cells that do not efficiently convert proTAME to its active parent compound (TAME) or if experiments demand strong APC/C inhibition.