bs-75506C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C.

Product Information:

CAS Number: 5142-23-4

Molecular formula: C6H7N5

Molecular weight: 149.2

Purity: >98%

Appearance: White to off-white solid.

Solubility: Soluble in DMSO, DMF, ethanol or water.

InChiKey: FSASIHFSFGAIJM-UHFFFAOYSA-N

SMILES: CN1C=NC(N)=C2N=CN=C12

Description:

Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K) [1, 7, 8]. Blocks class I, class II and class III PI3Ks, including some downstream targets [8]. Blocks class I PI3K persistently and class III PI3K transiently [7]. Induces autophagy under nutrient-rich conditions and inhibits starvation-induced autophagy due to differential effects on class I versus class III PI3 kinase [5, 7]. Shows some limited Vps34 preference in vitro compared to PtdIns3Kgamma. However, it is typically employed in cellular studies at a concentration of 10 mM, which can inhibit all PtdIns3Ks [8]. Can target other kinases and affect other cellular processes, such as glycogen metabolism, lysosomal acidification, endocytosis and mitochondrial permeability transition [2-4]. Anticancer compound [6, 10, 12]. Neuroprotective [9, 11]. PKA-activation dependent lipolytic agent. Enhances ATGL-dependent hydrolysis of triacylglycerols [13].