bs-75505C

DATASHEET

Formulation Solid

Storage: Stable for 2 years after receipt when stored at -20°C. Store solutions at -20°C in the dark.

Product Information:

CAS Number: 1214139-20-5; 144-90-1 (anhydrous)

Molecular formula: C4H9NO2 . H2O

Molecular weight: 103.1 . 18.0

Purity: >98% (TLC)

Appearance: White solid.

Solubility: Soluble in DMSO or water.

InChiKey: QCHPKSFMDHPSNR-UHFFFAOYSA-N

SMILES: CC(CN)C(O)=O

Description:

Catabolite of thymine [1-4]. Precursor for 3-Hydroxyisobutyric acid synthesis [3]. Small molecule myokine. Browning inducer of white adipose tissue (WAT) into brown adipose tissue (BAT) [9, 10]. PGC-1alpha-mediated and exercise-triggered nonadrenergic activator of the thermogenic program in WAT. Increases the expression of brown adipocyte-specific genes (browning) in white adipocytes and beta-oxidation in hepatocytes through a PPARalpha-mediated mechanism [9, 10]. Induces a brown adipose-like phenotype in human pluripotent stem cells and improves glucose homeostasis [9, 10]. Enhances fatty acid oxidation and reduces body weight in mice through an increased production of leptin by the white adipose tissue (WAT) [5-7]. Inhibits Agxt2-mediated metabolism of dimethylarginines [8]. Partial agonist of the glycine receptor (GlyR) [4].